Madrid Declaration on Ozonetherapy (2nd Edition)

The “Madrid Declaration on Ozone Therapy” is the first and only global consensus document in the history of ozone therapy. It has become an important reference tool for those health professionals using ozone therapy in any place in the world.

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It is an official document of ISCO3 (International Scientific Committee of Ozone Therapy).

The 2nd ed. of the Madrid Declaration reflects the latest medical and scientific advances occurred in the ozone therapy scientific world. Data summarized in this document are based on more than 2000 scientific publications, books and papers listed in the ISCO3 Ozone Therapy International Library.

The 1st. edition was issued on June 4, 2010. For its updating ISCO3 asked ozone therapist around the world to propose modifications and proposals. ISCO3 received a high and important number of them from very different countries.

The Madrid Declaration permits to work with specific objectives in a unified way assuring a practice with great precision and safety.

Buy either the online (15 Euros), available in Spanish, English and Arabic, or printed version (15 Euros + shipping costs), available in Spanish and English, of the 2nd. ed. of the Madrid Declaration at:

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Index of the “Madrid Declaration on Ozone Therapy, 2nd. ed., 2015, 50 pages”

    1. THERAPEUTIC BASIS
    2. OZONE THERAPY (O3X) BASIC PRINCIPLES

2.1 Contraindications
2.2 Interactions with ozone
2.3 Adverse effects
2.3.1 Grade 1 Mild
2.3.2 Grade 2 Moderate
2.3.3 Grade 3 Severe
2.3.4 Grade 4
2.3.5 Grade 5
2.4 Toxicity
2.5 Pediatrics dosages through rectal insufflations

    1. MAIN ROUTES OF APPLICATION

3.1 Recommended routes of application
3.1.1 Major Autohemotherapy (AHTmajor)
3.1.2 Minor Autohemotherapy (AHTminor)
3.1.3 Intramuscular, paravertebral and intrarticular injection
3.1.4 Paravertebral intramuscular injection
3.1.5 Hernias
3.1.6 Intradiscal Treatment
3.1.7 Sacral Hiatus/transluminal peridural infiltration
3.1.8 Intraforaminal infiltration
3.1.9 Intra-articular Treatment
3.1.10 The gloves technique (Emphysema subcutaneous technique)
3.1.11 Gasification in plastic bag
3.1.12 Subcutaneous application
3.1.13 Ozone suction cup
3.1.14 Insufflation in fistulas
3.1.15 Ophthalmologic
3.1.16 Vaginal insufflations
3.1.17 Insufflation vesico-urethral
3.1.18 Otic route
3.1.19 Intratonsillar infiltration route
3.1.20 Ozone micro doses in trigger and acupunture points
3.1.21 Subcutaneous application
3.1.22 Ozonized Saline Solution
3.1.23 Extracorporeal blood oxygenation-ozonation (EBOO)
3.1.24 Rectal Insufflation
3.2 Aplication routes not recommended for not being safe
3.2.1 Direct intraveous infection of ozone
3.2.2 Intra-arterial injection
3.3 Application route prohibitted
3.4 Application routes that have not received total consensus
3.4.1 Intra joint injection of ozonated water
3.4.2 Intra peritoneal
3.5 Essential requirements

    1. PATHOLOGIES MORE APPROPRIATE TO BE TREATED WITH OZONE THERAPY

4.1 Diseases in the level A
4.2 Diseases in the level B
4.3 Diseases in the level C

  1. GENERAL BASICS FOR TREATMENT
  2. BASIC RULES TO PERFORM TRAINING IN OZONE-THERAPY
  • ADDENDUM A. Clinical application of ozone in dentistry
  • ADDENDUM B. Mutagenicity, toxicity and adverse reactions in ozone therapy
  • REFERENCES
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